Dr. Anna L. Tan-Wilson

Dr. Anna L. Tan-Wilson

SUNY Distinguished Teaching Professor Emerita

BS, University of the Philippines
MSc, University College, London
PhD, University at Buffalo

Office: Science III - 110
Phone: 607-777-2651
Email: annatan@binghamton.edu
Website: https://www.researchgate.net/profile/Anna_Tan-Wilson/contributions

Research Interests:

Molecular biology, biochemistry and physiology of plants

One of the first enzymes to function in soybean germination is a subtilisin-like serine protease that degrades the protein reserves stored in the seed. Optimal cleavage requires binding to at least eight residues of a peptide substrate, explaining why this enzyme does not cleave the compact cupin domains of the storage globulins, only attacking regions N-terminal to those domains. This soy protease is already present in active form in the storage vacuoles of developing seed, but does not mobilize the storage proteins until after acidification of the vacuoles which occurs after germination. In developing seeds of the peanut, similar pH regulation keeps an aspartic protease from initiating utilization of the seed storage protein and food allergen, Ara h 1. The peanut enzyme targets the linker between the cupin domains, followed by cleavage at exposed loops within each of the cupin domains.

STEM education 

Selected projects include:

Revision of the requirements for the B.A. and B.S. Biology major
Hands-on proteomics work in Biochemistry Laboratory (NSF-funded)   
Interdisciplinary STEM Research Program in which STEM majors on campus worked under the guidance of faculty and graduate student mentors on projects in the life sciences that required collaboration with other STEM disciplines (HHMI-funded)  (http://www.binghamton.edu/undergraduate-research/hhmi/index.html?

 

Last Updated: 3/10/17