Ming An

Dr. Ming An

Assistant Professor, Organic Chemistry

  • B.S., University of Michigan, Ann Arbor, 1996
  • Ph.D., University of California, Berkeley, 2003
Science 2 Bldg - Room 229
Web page:

Research Interests:

My research interests are in the general areas of organic, bio-organic, medicinal, biological, and pharmaceutical chemistry, as well as chemical biology and drug discovery.

Selected Publications

Shu, N. S.; Chung, M. S.; Yao, L.; An, M.; Qiang, W.; “Residue-specific Structures and Membrane Locations of the pH-Low Insertion Peptide by Solid-state NMR Spectroscopy” Nature Communications, 2015, 6, 7787. doi: 10.1038/ncomms8787.

Onyango, J. O.; Chung, M. S.; Eng, C.-H.; Klees, L. M.; Langenbacher, R.; Yao, L.; An, M.; “Noncanonical Amino Acids Improve the pH-response of pHLIP Insertion at Tumor Acidity” Angew. Chem. Int. Ed. 2015, 54, 3658-3663.

Karabadzhak, A. G.; An, M.; Yao, L.; Langenbacher, R.; Moshnikova, A.; Adochite, R.; Andreev, O. A.; Reshetnyak, Y. K.; and Engelman, D. M.; “pHLIP-FIRE, a Cell Insertion-Triggered Fluorescent Probe for Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo” ACS Chem. Biol., 2014, 9, 2545-2553

An, M.; Wijesinghe, D.; Andreev, O.; Reshetnyak, Y.; and Engelman, D. M.; “pHLIP Translocation of Membrane Impermeable Phalloidin Toxin Inhibits Cancer Cell Proliferation” Proc. Natl. Acad. Sci. U.S.A., 2010, 107, 20246-20250.

Thevenin, D.; An, M.; and Engelman, D. M.; “pHLIP-Mediated Translocation of Membrane-Impermeable Molecules into Cells” Chemistry & Biology, 2009, 16, 754-762.

An, M.; Maitra U.; Neidlein, U. and Bartlett, P. A.; “5-Enolpyruvylshikimate-3-Phosphate Synthase: Chemical Synthesis of the Tetrahedral Intermediate and Assignment of the Stereochemical Course of the Enzymatic Reaction” J. Am. Chem. Soc., 2003, 125, 12759-12767.

Last Updated: 8/25/15