CHRISTOPHER R. BISHOP
Professor of Psychology
Ph.D., Wayne State University
Post-doctoral training: Wayne State University School of Medicine
Area: Behavioral Neuroscience
Office: Science IV, Room 363
Curriculum vitae (pdf, 346kb)
Member of the Society for Neuroscience, the Movement Disorders Society, International Basal Ganglia Society and the Center for Development and Behavioral Neuroscience
Parkinson's Disease, Neuroplasticity, Drug Development.
Movement is an ancient and basic function that is integral to the survival of the individual and species. As such, disorders of movement have a profound impact upon all facets of life. One of the most common movement disorders is Parkinson's disease, a neurodegenerative disorder that compromises dopaminergic areas of the brain rendering the individual unable to initiate, coordinate and execute movement. By employing an animal model of Parkinson's disease and a combination of behavioral, neurochemical and neuroanatomical techniques our laboratory examines the role of various neurotransmitters and neurocircuits responsible for this debilitating disorder. As importantly, we explore pharmacological targets within the brain that may aid in the development of more efficacious treatment for the Parkinsonian patient. Current projects, funded by the National Institute of Neurological Disease and Stroke and the Michael J. Fox Foundation investigate neuroplasticity in the brain serotonin system that may provide a novel target for the reduction of parkinsonian symptoms and side effects that occur as a result of chronic drug therapy.
Philosophy of Graduate Training:
My goal as a mentor is to provide students with the necessary tools, both theoretical and technical, to become productive independent researchers. Throughout the course of graduate curricula and laboratory experience, students will have the opportunity to develop a unique scientific approach and master a number of behavioral, neurochemical and neuroanatomical techniques that will lead to the design, execution and communication of sound and innovative research questions.
Lindenbach, D.L., Palumbo, N. Ostock, C.Y., Vilceus N., Conti, M.M. and Bishop, C. (2014). Side-effect profile of serotoninergic treatments for Parkinson's disease and L-DOPA-induced dyskinesia in rats. British Journal of Pharmacology (In Press).
Ostock, C.Y., Lindenbach, D.L. Goldenberg, A.A. Kampton, E. and Bishop, C. (2014). Effects of noradrenergic denervation by anti-DBH-saporin on behavioral responsivity to L-DOPA in the hemi-parkinsonian rat. Behavioural Brain Research, 270, 75-85.
Conti, M.M., Ostock, C.Y., Lindenbach, D.L., Goldenberg, A.A., Kampton, E., Dell'Isola, R., Katzman, A. and Bishop C. (2014). Effects of prolonged selective serotonin reuptake inhibition on the development and expression of L-DOPA-induced dyskinesia in hemiparkinsonian rats. Neuropharmacology, 77, 1-8.
Lindenbach, D.L. and Bishop, C. (2013). Critical involvement of the motor cortex in the pathophysiology and treatment of Parkinson's disease. Neuroscience and Biobehavioral Reviews, 37, 2737-2750.
Dupre, K.B., Ostock C.Y., George, J.A., Eskow Jaunarajs, K.L., Hueston C.M. and Bishop, C. (2013). 5-HT1A receptor stimulation enhances GABAergic activity in the striatonigral pathway in a D1R-mediated model of dyskinesia. ASC Chemical Neuroscience, 4(5), 747-760.