Sauer's research group utilizes the model organism Pseudomonas aeruginosa to elucidate regulatory and signaling events underlying the formation and development of highly antimicrobial resistant biofilms. They are specifically interested in differential gene expressions coinciding with the formation and dispersion of biofilms, the role of posttranslational modifications in enabling bacteria to sense and respond to environmental conditions, and the mechanism by which biofilm cells gain their heightened resistance to antimicrobial agents. The overall goal of their research is to identify factors to control and manage biofilms and their extraordinary resistance to antimicrobial agents.
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