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Christof T. Grewer

Christof T. Grewer

Professor of Biophysical Chemistry
and Chair of Graduate Admissions Committee

  • Diploma in Chemistry (equivalent to M.S.), Johann Wolfgang Goethe-University, Frankurt, Germany, 1990
  • Ph.D. in Physical Chemistry, Johann Wolfgang Goethe-University, Frankfurt, Germany, 1993
Smart Energy bldg - 1042
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Research Interests:

The long-term goal of our research is to understand the function and the working mechanism of membrane-bound transport proteins. In general, transporters use different types of energy sources to actively move specific substrates, such as inorganic ions or small, organic molecules across the membrane into or out of cells. Recently, significant progress has been made towards our understanding of the molecular architecture through the availability of high-resolution structures of several transporters. However, the actual transport mechanism(s) remain elusive. Our aim is to combine functional and structural evidence in order to obtain an understanding of how these transport proteins work.

Selected Publications

Garibsingh RA, Otte NJ, Ndaru E, Colas C, Grewer C, Holst J, Schlessinger A. Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2. Front Chem. 2018 Jul 24;6:279. doi: 10.3389/fchem.2018.00279. eCollection 2018. PubMed PMID: 30137742; PubMed Central PMCID: PMC6066518

Wang J, Albers T, Grewer C. Energy Landscape of the Substrate Translocation Equilibrium of Plasma-Membrane Glutamate Transporters. J Phys Chem B. 2018 Jan
11;122(1):28-39. doi: 10.1021/acs.jpcb.7b09059. Epub 2017 Dec 22. PubMed PMID: 29218993.

Singh K, Tanui R, Gameiro A, Eisenberg G, Colas C, Schlessinger A, Grewer C. Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2. Bioorg Med Chem Lett. 2017 Feb 1;27(3):398-402. doi:10.1016/j.bmcl.2016.12.063. Epub 2016 Dec 27. PubMed PMID: 28057420; PubMed
Central PMCID: PMC5363072.

Hanz SZ, Shu NS, Qian J, Christman N, Kranz P, An M, Grewer C, Qiang W. Protonation-Driven Membrane Insertion of a pH-Low Insertion Peptide. Angew Chem
Int Ed Engl. 2016 Sep 26;55(40):12376-81. doi: 10.1002/anie.201605203. Epub 2016 Aug 31. PubMed PMID: 27578553.

Tanui R, Tao Z, Silverstein N, Kanner B, Grewer C. Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1. J Biol Chem. 2016 May 27;291(22):11852-64. doi: 10.1074/jbc.M116.722470. Epub 2016 Apr 4. PubMed PMID: 27044739; PubMed Central PMCID: PMC4882452.

Last Updated: 2/5/19