Dr. Sozanne R. Solmaz
Assistant Professor of Biological Chemistry
- M.S., Leibniz University of Hannover, Germany, 2001
- Ph.D., Max Planck Institute of Biophysics and Goethe University, Frankfurt, Germany, 2006
Office: Smart Energy bldg - room 1045
Group page: http://chemiris.chem.binghamton.edu/SOLMAZ/solmaz.html
Nuclear pore complexes are central gatekeepers of the cell nucleus, and facilitate selective transport of cargo between the cytoplasm and nucleus. As such, they regulate crucial cellular processes such as cell division, RNA metabolism and gene expression. We apply x-ray crystallography to visualize the protein components of this large macromolecular machinery at atomic resolution. Our interdisciplinary approach integrates methods of chemistry, physics, medicine and biology and will give insights into cancer formation, cell division and cell differentiation.
Recent Selected Publications
Noell, CR, Loh, JY, Debler, EW, Loftus KM, Cui, H, Russ, BB, Goyal, P, and Solmaz,
SR*. Role of coiled-coil registry shifts in activation of human Bicaudal D2 for dynein
recruitment upon cargo-binding. BioRxiv 638536 [Preprint]. May 15, 2019. Available from doi: https://doi.org/10.1101/638536.
Noell CR, Loftus KM, Cui H, Grewer CT, Kizer M, Debler EW, Solmaz SR*. A quantitative
model for BicD2/cargo interactions. Biochemistry, 2018, 57: 6538-6550. doi: 10.1021/acs.biochem.8b00987.
Cui, H, Loftus, KM, Noell, CR, and SOLMAZ, SR*. Identification of cyclin-dependent
kinase 1 specific phosphorylation sites by an in vitro kinase assay. J Vis Exp, 2018, 135. doi: 10.3791/57674
Solmaz, SR (2018). Chapter Six - On the roles of channel nucleoporins in nuclear transport.
In: Nucleic Acids Mol Biol, Volume on Nuclear-Cytoplasmic Transport. Edited by Yang, W. Springer. Invited book
chapter, 2018, 33, 65-112.
Loftus, KL, Cui, H, Coutavas, E, King, DS , Ceravolo, A, Pereiras, D, and Solmaz,
SR*. Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F.
Cell Cycle, 2017, 16:1414-1429. doi: 10.1080/15384101.2017.1338218.
Sharma, A1, Solmaz, SR1, Blobel, G and Melcak, I. Ordered Regions of Channel Nucleoporins Nup62, Nup54 and Nup58 Form Dynamic Complexes in Solution. J Biol Chem 2015 290: 18370-1837. 1First authors, equally contributed. Selected as Journal cover.
Solmaz, SR*, Blobel, G* and Melcak, I*. Ring cycle for dilating and constricting the nuclear pore. Proc Natl Acad Sci U S A 2013 110: 5858-5863**.
Selected as science highlight by Advanced Light Source (ALS) synchrotron, Berkeley, CA.
Solmaz, SR, Chauhan, R, Blobel, G, and Melcak, I. Molecular architecture of the transport channel of the nuclear pore complex. Cell 2011 147: 590-602.
Solmaz, SR, and Hunte, C. Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer. J Biol Chem 2008 283: 17542-17549.
Hunte, C, Solmaz, S, Palsdottir, H, and Wenz, T. A structural perspective on mechanism and function of the cytochrome bc1 complex. Results Probl Cell Differ 2008 45: 253-278.
Hunte, C, Solmaz, S, and Lange, C. Electron transfer between yeast cytochrome bc1 complex and cytochrome c: a structural analysis. Biochim Biophys Acta 2002 1555: 21-28.