Bio-Inspired Microsystems Engineering Lab

Bio-Inspired Microsystems Engineering Lab

About the lab

The research aim of our lab is developing unconventional organoid systems and organs-on-chips for biomedical and pharmaceutical applications.

The research focus also extends to the creation of microphysiological systems integrated with microengineered devices to investigate the impact of biophysical signals on human health and disease.​

To this end, three immediate topics are:

  • microengineered human organoids-on-chips
  • microphysiological models of disease-induced vascular disorders
  • tissue-engineered 3D models of human physiological systems

About Professor Paek

Jungwook "Jay" Paek is an assistant professor in the Department of Electrical and Computer Engineering at Binghamton University (State University of New York).

He is passionate about combining multiple engineering approaches to reverse engineer complex living systems for improving human health and wellbeing.

In particular, Paek is interested in developing microphysiological systems
based on organ-on-a-chip and organoid technologies to study disease processes in the human respiratory and vascular systems.

Previously, Paek was a research associate in the Department of Bioengineering at University of Pennsylvania, where he worked on in vitro modeling of human tissues and organs.

Prior to his postdoctoral work, Jay received his PhD in electrical engineering from Iowa State University, with his primary research centered on the design, fabrication and application of bio-inspired elastomeric microsystems.

Publications

  • Jungwook Paek, Lakshminarayan Reddy Teegala, Farid Alisafaei, Geremy C. Clair, Joseph W. Song, Sunghee E. Park, Charles K. Ansong, Mark J. Mondrinos, Vivek Shenoy, Charles Thodeti, Sailaja M. Paruchuri, and Dongeun Huh, "A microengineered model of mechanical force-induced tissue remodeling in human lungs," Submitted.
  • Sunghee E. Park, Shawn Kang, Jungwook Paek, Andrei Georgescu, Alex Yi, and Dongeun Huh, "Geometric engineering of organoid culture for enhanced organogenesis in a dish," Nat Methods, 19, 1449-1460 (2022)
  • Jungwook Paek, Joseph W. Song, Ehsan Ban, Yuma Morimitsu, Chinedum O. Osuji, Vivek B. Shenoy, and Dan Dongeun Huh, "Soft robotic constrictor for in vitro modeling of dynamic tissue compression," Scientific Reports, 11, 16478 (2021)
  • Jungwook Paek, Sunghee E. Park, Qiaozhi Lu, Kyu-Tae Park, Minseon Cho, Jeong Min Oh, Keon Woo Kwon, Yoon-suk Yi, Joseph W. Song, Hailey I. Edelstein, Jeff Ishibashi, Wenli Yang, Jacob W. Myerson, Raisa Y. Kiseleva, Pavel Aprelev, Elizabeth D. Hood, Dwight Stambolian, Patrick Seale, Vladimir R. Muzykantov, and Dongeun Huh, "Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues," ACS Nano, 13(7), 7627-7643 (2019)
  • Joseph W. Song, Jungwook Paek, Kyu-Tae Park, Jeongyun Seo, and Dan Dongeun Huh, "A bioinspired microfluidic model of liquid plug-induced mechanical airway injury," Biomicrofluidics, 12(4), 042211 (2018)
  • Jungwook Paek, Qiang Li, Inho Cho, and Jaeyoun Kim, “Minimally Intrusive Optical Micro-Strain Sensing in Bulk Elastomer Using Embedded Fabry-Pérot Etalon”, Micromachines, 7(4), 61 (2016)
  • Jungwook Paek, Inho Cho, and Jaeyoun Kim, “Microrobotic tentacles with spiral bending capability based on shape-engineered elastomeric microtubes”, Scientific Reports, 5, 10768 (2015)
  • Jungwook Paek and Jaeyoun Kim, “Bokeh microscope-integrated micro channels for facile point-of-care monitoring”, Biomedical Microdevices, 17(1), 13 (2015)
  • Jungwook Paek and Jaeyoun Kim, "Microsphere-assisted fabrication of high aspect-ratio elastomeric micropillars and waveguides," Nature Communications, 5, 3324 (2014)
  • Jungwook Paek and Jaeyoun Kim, "Building Freestanding Elastomeric Waveguides: Exploring an Emerging Field," to appear in Optics & Photonics News, 11, 18 (2014)
  • Jiwon Lee, Jungwook Paek (co-first author), and Jaeyoun Kim, "A biomimetic mass-flow transducer utilizing all-optofluidic generation of self-digitized, pulse code-modulated optical pulse trains," Lab on a Chip, 12(19), 3766-3773 (2012)
  • Jiwon Lee, Jungwook Paek, and Jaeyoun Kim, "Sucrose-based fabrication of 3D-networked, cylindrical microfluidic channels for rapid prototyping of lab-on-a-chip and vaso-mimetic devices," Lab on a Chip, 12(15), 2638-2642 (2012)

Lab opening

The Bio-Inspired Microsystems Engineering Lab seeks a PhD student. Contact Professor Paek for more information.