Perfusable Microfluidic Platform for In Vitro Vascularization of 3D Human Tissues
We develop advanced microfluidic platforms and microvascular engineering strategies to create perfusable vascular networks in human 3D tissue constructs entirely in vitro, eliminating the need for animal hosts. This approach enables the formation of larger, physiologically relevant issues, providing a robust platform for disease modeling, drug delivery studies, and therapeutic testing.
Breast Cancer Metastasis-on-Chip
We pioneer a multi-organ-on-chip system to model breast cancer metastasis. By leveraging a unidirectional, pumpless perfusion design, we incorporate circulating cancer cells into a multi-organ microphysiological system (MPS) to study key metastatic processes and evaluate therapeutic responses.
Composite Biomaterials for Tissue Engineering
We engineer composite hydrogels and advanced scaffold materials tailored to support microvascular formation and bone regeneration. These biomaterials provide essential structural and biochemical cues, enabling precise control over tissue growth and function for applications in regenerative medicine and disease modeling.
Biological Validation with Body-on-Chip for In Silico AI-Based Drug Discovery
We integrate body-on-chip systems with AI-driven in silico drug discovery pipelines to accelerate therapeutic development.
Metastatic Brain Tumor Modeling from Patient-derived Brain Metastases
Funded by the BU Watson UHS Collaboration Seed Grant, this project focuses on developing metastatic brain tumor models using patient-derived tissues. These models will serve as platforms for drug testing and disease modeling.
